Rat Neurofibromin (NF1) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat Neurofibromin (NF1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx520735
tested applications
ELISA
Description
Rat Neurofibromin (NF1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Neurofibromin concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Neurofibromin (NF1) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.078 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P97526 |
| Alias | WSS,NFNS,VRNF,Neurofibromatosis-related protein NF-1,Neurofibromin |
| Background | Elisa kits for NF1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Neurofibromin 1 (NF1) is a tumor suppressor protein that plays a critical role in regulating cell growth, differentiation, and survival NF1 functions primarily as a negative regulator of the RAS signaling pathway, which is involved in cellular processes such as proliferation, differentiation, and survival By hydrolyzing GTP to GDP, neurofibromin inactivates RAS, thus preventing uncontrolled cell growth and the formation of tumors Neurofibromin is expressed in various tissues, including the nervous system, where it helps maintain normal neurodevelopment and prevent tumor formation Disruptions or mutations in the NF1 gene lead to neurofibromatosis type 1 (NF1), a genetic disorder characterized by the development of benign tumors, called neurofibromas, along nerves Additionally, NF1 mutations are associated with an increased risk of malignant tumors, learning disabilities, and other neurological symptoms The role of NF1 in tumor suppression and cellular signaling makes it an important target for therapeutic interventions aimed at managing neurofibromatosis and related cancers
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