Neurofibromin (NF1) Antibody
377€ (100 µg)
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Name
Neurofibromin (NF1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx217147
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
Neurofibromin (NF1) Antibody is a Rabbit Polyclonal antibody for the detection of Neurofibromin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neurofibromin (NF1) Immunogen: Neurofibromin |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/500, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 319 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21359 |
| Gene ID | 4763 |
| OMIM | 114500 |
| Alias | WSS,NFNS,VRNF,Neurofibromatosis-related protein NF-1,Neurofibromin |
| Background | Antibody anti-NF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Neurofibromin 1 (NF1) is a tumor suppressor protein that plays a critical role in regulating cell growth, differentiation, and survival NF1 functions primarily as a negative regulator of the RAS signaling pathway, which is involved in cellular processes such as proliferation, differentiation, and survival By hydrolyzing GTP to GDP, neurofibromin inactivates RAS, thus preventing uncontrolled cell growth and the formation of tumors Neurofibromin is expressed in various tissues, including the nervous system, where it helps maintain normal neurodevelopment and prevent tumor formation Disruptions or mutations in the NF1 gene lead to neurofibromatosis type 1 (NF1), a genetic disorder characterized by the development of benign tumors, called neurofibromas, along nerves Additionally, NF1 mutations are associated with an increased risk of malignant tumors, learning disabilities, and other neurological symptoms The role of NF1 in tumor suppression and cellular signaling makes it an important target for therapeutic interventions aimed at managing neurofibromatosis and related cancers
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