Rat Natriuretic Peptide Receptor 3 (NPR3) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein NPR3
proveedor
Abbexareference
abx168540Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Natriuretic Peptide Receptor 3 Protein is a recombinant Rat protein expressed in E. coli.
Background
NPR3, also known as the natriuretic peptide clearance receptor, binds all three natriuretic peptides (ANP, BNP, and CNP) but does not have intrinsic guanylyl cyclase activity. Instead, NPR3 functions as a clearance receptor, removing natriuretic peptides from circulation and modulating their bioavailability and effects. NPR3 is expressed in various tissues, including the heart, kidney, and vascular system, where it regulates peptide levels to maintain cardiovascular and renal homeostasis. NPR3's role in limiting natriuretic peptide activity impacts blood pressure regulation, vascular remodeling, and fluid balance. Genetic polymorphisms in NPR3 have been linked to hypertension, heart failure, and obesity, highlighting its role in metabolic and cardiovascular health. In addition to clearance, NPR3 signaling influences cellular processes through its ability to couple with inhibitory G proteins, affecting cAMP levels and downstream pathways. NPR3-mediated clearance of CNP is critical for controlling vascular tone and endothelial function, underscoring its regulatory importance. Recent studies suggest that modulating NPR3 activity could enhance natriuretic peptide signaling, offering therapeutic potential for managing cardiovascular and metabolic disorders.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Natriuretic Peptide Receptor 3 (NPR3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 53.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Val214 + KHHHHHHHH Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
NPR3
dry ice
No
availability
Shipped within 5-7 working days.
alias
NPRC,ANP-C,ANPRC,BOMOS,NPR-C,ANPR-C,GUCY2B,C5orf23,Atrial natriuretic peptide receptor type C,Atrial natriuretic peptide clearance receptor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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