NPR3 antibody
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935106861
info@markelab.com
name
NPR3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05824
tested applications
ELISA, IHC
Description
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | chromosome 5 open reading frame 23 (NPR3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P17342 |
| Gene ID | 4883 |
| Alias | NPRC,ANP-C,ANPRC,BOMOS,NPR-C,ANPR-C,GUCY2B,C5orf23,Atrial natriuretic peptide receptor type C,Atrial natriuretic peptide clearance receptor |
| Background | Antibody anti-NPR3 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
NPR3, also known as the natriuretic peptide clearance receptor, binds all three natriuretic peptides (ANP, BNP, and CNP) but does not have intrinsic guanylyl cyclase activity. Instead, NPR3 functions as a clearance receptor, removing natriuretic peptides from circulation and modulating their bioavailability and effects. NPR3 is expressed in various tissues, including the heart, kidney, and vascular system, where it regulates peptide levels to maintain cardiovascular and renal homeostasis. NPR3's role in limiting natriuretic peptide activity impacts blood pressure regulation, vascular remodeling, and fluid balance. Genetic polymorphisms in NPR3 have been linked to hypertension, heart failure, and obesity, highlighting its role in metabolic and cardiovascular health. In addition to clearance, NPR3 signaling influences cellular processes through its ability to couple with inhibitory G proteins, affecting cAMP levels and downstream pathways. NPR3-mediated clearance of CNP is critical for controlling vascular tone and endothelial function, underscoring its regulatory importance. Recent studies suggest that modulating NPR3 activity could enhance natriuretic peptide signaling, offering therapeutic potential for managing cardiovascular and metabolic disorders.
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