Rat Mu-type opioid receptor (OPRM1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for OPRM1
proveedor
Abbexareference
abx513815Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Mu-type opioid receptor (OPRM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Mu-type opioid receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
OPRM1, or the mu-opioid receptor, is the primary target for endogenous opioid peptides like endorphins and exogenous opioids such as morphine, fentanyl, and heroin. OPRM1 is highly expressed in pain-processing regions of the CNS, including the brainstem, thalamus, and spinal cord, where it mediates analgesia, euphoria, and sedation. OPRM1 couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating ion channels to decrease neuronal excitability and neurotransmitter release. Activation of OPRM1 produces potent analgesic effects but also carries risks of tolerance, dependence, and respiratory depression. Dysregulation of OPRM1 signaling is central to opioid addiction, chronic pain, and reward pathways. Selective modulation of OPRM1 has therapeutic potential for improving pain management while reducing side effects such as tolerance and dependence. Biased agonists that preferentially activate analgesic pathways over adverse effects are under development to enhance safety. OPRM1 remains a key target for opioids and therapies addressing addiction and pain disorders.
Características del producto
category
ELISA Kits
immunogen target
Mu-type opioid receptor (OPRM1)
reactivity
Rat
test range
31.2 pg/ml - 2000 pg/ml
sensitivity
< 15.65 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
OPRM1,Mu receptor,MOP,OP3,MOPr,opioid receptor,mu 1,opioid receptor,MOR,LMOR,MOR1,OPRM,M-OR-1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
OPRM1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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