Rat Midkine (MDK) Protein
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Description
Rat Midkine (MDK) is a recombinant Rat protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Midkine (MDK) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ala22-Asp140 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 18.8 kDa Observed MW (SDS-PAGE): 17 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9R1S9 |
| Background | Protein MDK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
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Midkine (MDK) Antibody
MDK Antibody is a Rabbit Polyclonal antibody against MDK. Midkine, or MDK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MDK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MDK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MDK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MDK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MDK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MDK functions to enhance the activity of plasminogen activator (PA).
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Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis (summary by Reynolds et al., 2004 [PubMed 15197188]).
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