Midkine (MDK) Antibody
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Description
MDK Antibody is a Rabbit Polyclonal antibody against MDK. Midkine, or MDK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MDK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MDK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MDK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MDK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MDK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MDK functions to enhance the activity of plasminogen activator (PA).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Midkine (MDK) Immunogen: Recombinant protein corresponding to MDK. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/100 - 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 16 kDa Observed MW: 16 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21741 |
| Gene ID | 4192 |
| NCBI Accession | NP_001012333.1 |
| Background | Antibody anti-MDK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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Midkine (MDK) Antibody
MDK Antibody is a Rabbit Polyclonal antibody against MDK. Midkine, or MDK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MDK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MDK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MDK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MDK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MDK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MDK functions to enhance the activity of plasminogen activator (PA).
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Midkine (MDK) Antibody
Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis (summary by Reynolds et al., 2004 [PubMed 15197188]).
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