Rat Melanoma-Derived Growth Regulatory Protein (MIA) Protein

Este producto es parte de MIA - MIA SH3 domain containing
Rat Melanoma-Derived Growth Regulatory Protein (MIA) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein MIA

proveedor

Abbexa

reference

abx167946

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Melanoma-Derived Growth Regulatory Protein (MIA) is a recombinant Rat protein expressed in E. coli.


Background

MIA, also known as Melanoma Inhibitory Activity, is a small secreted protein primarily expressed in melanocytes and chondrocytes, where it regulates cell adhesion, migration, and tumor progression It acts by disrupting the interaction between integrins and the extracellular matrix, facilitating detachment and migration of tumor cells MIA is highly expressed in malignant melanoma and is used as a biomarker for disease progression, metastasis, and treatment monitoring Elevated MIA levels are also observed in other cancers, such as chondrosarcoma and hepatocellular carcinoma, where it contributes to tumor invasiveness Its role extends to cartilage homeostasis and chondrocyte differentiation, implicating MIA in cartilage-related disorders like osteoarthritis Targeting MIA holds therapeutic potential in inhibiting tumor cell dissemination and cartilage degeneration

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Melanoma-Derived Growth Regulatory Protein (MIA)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 42.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala36-Phe127 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

MIA


dry ice

No


availability

Shipped within 5-7 working days.


alias

Melanoma inhibitory activity protein,MIA1,CD-RAP


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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