Rat Mast / Stem Cell Growth Factor Receptor (KIT) Protein
780€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Rat Mast / Stem Cell Growth Factor Receptor (KIT) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692450
Tested Applications
SDS-PAGE
Description
Mast / Stem Cell Growth Factor Receptor (KIT) protein is a recombinant Rat protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Mast / Stem Cell Growth Factor Receptor (KIT) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Thr522 Tag: C-terminal His tag |
| Origin | Rat |
| Observed MW | 56.9 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q63116 |
| Alias | Mast/stem cell growth factor receptor Kit,PBT,SCFR,C-Kit,CD117,MASTC,Piebald trait protein (PBT),Proto-oncogene c-Kit,Proto-oncogene c-Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Background | Protein KIT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
The KIT protein, also known as the KIT receptor tyrosine kinase or CD117, is a proto-oncogene that encodes a transmembrane receptor. It plays essential roles in cell growth, survival, migration, and differentiation in several types of cells, especially in hematopoietic stem cells, germ cells, melanocytes, and cells in the gastrointestinal tract. The gene encoding KIT is located on chromosome 4q12 and is highly conserved across species, highlighting its fundamental role in development and cellular homeostasis. KIT is activated by binding to its ligand, stem cell factor (SCF), also known as mast cell growth factor. This binding triggers a cascade of downstream signaling pathways critical for normal cellular processes. However, mutations in KIT can result in its constitutive activation, which is implicated in various diseases, including gastrointestinal stromal tumors (GISTs), systemic mastocytosis, acute myeloid leukemia (AML), and other cancers. As a proto-oncogene, KIT’s aberrant signaling due to mutation can drive tumorigenesis, making it a target for cancer therapies, particularly tyrosine kinase inhibitors (TKIs).
Productos relacionados
KIT (pY721) Antibody
KIT (pY721) Antibody is a Rabbit Polyclonal antibody against KIT (pY721). This gene encodes the human homolog of the pro…
Ver producto
Mast/stem Cell Growth Factor Receptor Kit (c-Kit) Antibody
c-Kit Antibody is a Rabbit Polyclonal Antibody against c-Kit.…
Ver producto
Mast/stem Cell Growth Factor Receptor Kit (C-Kit) Antibody
C-kit (CD117, 145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (st…
Ver producto