Mast/stem Cell Growth Factor Receptor Kit (C-Kit) Antibody

Este producto es parte de KIT - KIT receptor tyrosine kinase ( proto oncogene)
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383.5€ (100 µl)

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935106861
info@markelab.com
name
Mast/stem Cell Growth Factor Receptor Kit (C-Kit) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010475
tested applications
ELISA, IHC

Description

C-kit (CD117, 145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c-kit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Mast/stem Cell Growth Factor Receptor Kit (C-Kit)
Host
Mouse
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purification
Unpurified ascites.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
Ascitic fluid containing 0.03% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P10721
Gene ID
3815
OMIM
154800
Alias
Mast/stem cell growth factor receptor Kit,PBT,SCFR,C-Kit,CD117,MASTC,Piebald trait protein (PBT),Proto-oncogene c-Kit,Proto-oncogene c-Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Background
Antibody anti-KIT
Status
RUO
Note
Concentration: Not determined. -

Descripción

The KIT protein, also known as the KIT receptor tyrosine kinase or CD117, is a proto-oncogene that encodes a transmembrane receptor. It plays essential roles in cell growth, survival, migration, and differentiation in several types of cells, especially in hematopoietic stem cells, germ cells, melanocytes, and cells in the gastrointestinal tract. The gene encoding KIT is located on chromosome 4q12 and is highly conserved across species, highlighting its fundamental role in development and cellular homeostasis. KIT is activated by binding to its ligand, stem cell factor (SCF), also known as mast cell growth factor. This binding triggers a cascade of downstream signaling pathways critical for normal cellular processes. However, mutations in KIT can result in its constitutive activation, which is implicated in various diseases, including gastrointestinal stromal tumors (GISTs), systemic mastocytosis, acute myeloid leukemia (AML), and other cancers. As a proto-oncogene, KIT’s aberrant signaling due to mutation can drive tumorigenesis, making it a target for cancer therapies, particularly tyrosine kinase inhibitors (TKIs).

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