Rat Leucine-Rich Repeat-Containing Protein 4 (LRRC4) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat Leucine-Rich Repeat-Containing Protein 4 (LRRC4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx531569
tested applications
ELISA
Description
Rat Leucine-Rich Repeat-Containing Protein 4 (LRRC4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Leucine-rich repeat-containing protein 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 4 (LRRC4) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q45R42 |
| Alias | Netrin-G2 ligand (NGL-2) |
| Background | Elisa kits for LRRC4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LRRC4, also known as netrin-G ligand 2 (NGL-2), is a leucine-rich repeat-containing protein involved in synaptic organization, neuronal development, and cell signaling. It serves as a postsynaptic adhesion molecule that interacts with netrin-G2, facilitating synapse formation, maintenance, and stability in the central nervous system. LRRC4 is highly expressed in the brain, particularly in regions associated with synaptic plasticity, learning, and memory. It regulates axon guidance, dendritic development, and excitatory synaptic transmission by interacting with cytoskeletal proteins and signaling molecules. Dysregulation or mutations in LRRC4 are associated with neurological disorders, including autism spectrum disorders (ASD) and intellectual disabilities, where impaired synaptic organization disrupts neuronal connectivity. LRRC4 also exhibits tumor-suppressive properties in gliomas by inhibiting cell proliferation, migration, and survival pathways. Knockout studies reveal impaired synaptic function, altered dendritic morphology, and reduced neuronal connectivity, highlighting its essential role in neural circuit development, synaptic organization, and brain function.
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