Leucine-Rich Repeat-Containing Protein 4 (LRRC4) Antibody
292.5€ (80 µl)
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 4 (LRRC4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034410
tested applications
ELISA, WB, IHC
Descripción del producto
The exact function of LRRC4 is unknown.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | Netrin-G2 ligand (NGL-2) |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-LRRC4 |
| Buffer | PBS containing 0.09% sodium azide. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Host | Rabbit |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 4 (LRRC4) |
| Isotype | IgG |
| Name | Leucine-Rich Repeat-Containing Protein 4 (LRRC4) Antibody |
| Price | 292.5 |
| Provider | Abbexa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx034410 |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB, IHC |
| UniProt ID | Q9HBW1 |
Descripcion del producto en español
Background en español
LRRC4, also known as netrin-G ligand 2 (NGL-2), is a leucine-rich repeat-containing protein involved in synaptic organization, neuronal development, and cell signaling. It serves as a postsynaptic adhesion molecule that interacts with netrin-G2, facilitating synapse formation, maintenance, and stability in the central nervous system. LRRC4 is highly expressed in the brain, particularly in regions associated with synaptic plasticity, learning, and memory. It regulates axon guidance, dendritic development, and excitatory synaptic transmission by interacting with cytoskeletal proteins and signaling molecules. Dysregulation or mutations in LRRC4 are associated with neurological disorders, including autism spectrum disorders (ASD) and intellectual disabilities, where impaired synaptic organization disrupts neuronal connectivity. LRRC4 also exhibits tumor-suppressive properties in gliomas by inhibiting cell proliferation, migration, and survival pathways. Knockout studies reveal impaired synaptic function, altered dendritic morphology, and reduced neuronal connectivity, highlighting its essential role in neural circuit development, synaptic organization, and brain function.
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