Rat Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits KIR3DL1
proveedor
Abbexareference
abx529948Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Killer cell immunoglobulin-like receptor 3DL1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Killer Cell Immunoglobulin-Like Receptor 3DL1 (KIR3DL1) is a member of the KIR family, expressed on natural killer (NK) cells and a subset of T lymphocytes, playing a critical role in modulating immune responses. This receptor binds specifically to HLA class I molecules, particularly HLA-B alleles with the Bw4 motif, allowing NK cells to recognize and monitor the health of target cells. When KIR3DL1 engages its ligand, it delivers inhibitory signals that suppress NK cell cytotoxic activity, thus maintaining immune homeostasis and preventing autoreactivity. Variations in KIR3DL1, including polymorphisms and expression levels, are associated with differential susceptibility to infectious diseases, cancer, and autoimmune conditions. Studies have also highlighted its significance in allogeneic hematopoietic stem cell transplantation, where KIR-HLA mismatches can influence graft-versus-leukemia effects and transplantation outcomes. By regulating NK cell activity, KIR3DL1 contributes to the delicate balance between immune surveillance and tolerance, making it a valuable target for therapeutic interventions in cancer immunotherapy and immune-mediated disorders.
Características del producto
category
ELISA Kits
immunogen target
Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
CD158 antigen-like family member E,HLA-BW4-specific inhibitory NK cell receptor,CD158E,NKAT3,NKB1Natural killer-associated transcript 3,KIR,NKB1,NKAT3,NKB1B,NKAT-3,CD158E1,KIR2DL5B,KIR3DL1/S1
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
KIR3DL1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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