Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) Antibody
195€ (20 µl)
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935106861
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name
Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001361
tested applications
ELISA, WB
Description
KIR3DL1 Antibody is a Rabbit Polyclonal antibody against KIR3DL1. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43629 |
| Gene ID | 3811 |
| NCBI Accession | NP_037421.2 |
| Alias | CD158 antigen-like family member E,HLA-BW4-specific inhibitory NK cell receptor,CD158E,NKAT3,NKB1Natural killer-associated transcript 3,KIR,NKB1,NKAT3,NKB1B,NKAT-3,CD158E1,KIR2DL5B,KIR3DL1/S1 |
| Background | Antibody anti-KIR3DL1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
Killer Cell Immunoglobulin-Like Receptor 3DL1 (KIR3DL1) is a member of the KIR family, expressed on natural killer (NK) cells and a subset of T lymphocytes, playing a critical role in modulating immune responses. This receptor binds specifically to HLA class I molecules, particularly HLA-B alleles with the Bw4 motif, allowing NK cells to recognize and monitor the health of target cells. When KIR3DL1 engages its ligand, it delivers inhibitory signals that suppress NK cell cytotoxic activity, thus maintaining immune homeostasis and preventing autoreactivity. Variations in KIR3DL1, including polymorphisms and expression levels, are associated with differential susceptibility to infectious diseases, cancer, and autoimmune conditions. Studies have also highlighted its significance in allogeneic hematopoietic stem cell transplantation, where KIR-HLA mismatches can influence graft-versus-leukemia effects and transplantation outcomes. By regulating NK cell activity, KIR3DL1 contributes to the delicate balance between immune surveillance and tolerance, making it a valuable target for therapeutic interventions in cancer immunotherapy and immune-mediated disorders.
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