Rat Interleukin 10 (IL10) Protein

Este producto es parte de IL10 - Interleukin 10
Rat Interleukin 10 (IL10) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein IL10

proveedor

Abbexa

reference

abx168557

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Interleukin 10 Protein is a recombinant Rat protein expressed in E. coli.


Background

IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Interleukin 10 (IL10)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 22.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser19-Asn178 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL10


dry ice

No


availability

Shipped within 5-7 working days.


alias

CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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