Rat Integrin Alpha M / CD11b (ITGAM) Protein

Este producto es parte de ITGAM - integrin subunit alpha M
Rat Integrin Alpha M / CD11b (ITGAM) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ITGAM

proveedor

Abbexa

reference

abx067283

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Integrin alpha M (ITGAM)(ITGAM) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

Integrin Subunit Alpha M (ITGAM), also known as CD11b, is a transmembrane glycoprotein expressed predominantly on the surface of monocytes, macrophages, granulocytes, and some dendritic cells. ITGAM forms a heterodimer with integrin beta-2 (ITGB2) to create the Mac-1 complex, which is crucial in mediating adhesion and migration of leukocytes during inflammatory and immune responses. The protein plays a pivotal role in immune surveillance and host defense by facilitating phagocytosis, complement receptor activity, and migration across endothelial barriers. Additionally, ITGAM is involved in the recognition and clearance of pathogens and apoptotic cells. Aberrations in ITGAM expression or mutations have been linked to systemic lupus erythematosus (SLE) and other autoimmune disorders. It is also a key player in immune evasion mechanisms employed by certain pathogens.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Integrin Alpha M / CD11b (ITGAM)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 15.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala31-Ser160 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ITGAM


dry ice

No


availability

Shipped within 5-12 working days.


alias

CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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