Rat Integrin Alpha 6 (ITGa6) Protein
208€ (10 µg)
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Name
Rat Integrin Alpha 6 (ITGa6) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx653894
Tested Applications
WB, SDS-PAGE
Description
Rat Integrin Alpha 6 (ITGa6) Protein is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Integrin Alpha 6 (ITGa6) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | JEB6,CD49f,VLA-6,ITGA6A,ITGA6B,Integrin alpha-6,CD49 antigen-like family member F |
| Background | Protein ITGA6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Integrin subunit alpha 6 (ITGA6) is part of the integrin family, a group of transmembrane receptors that mediate cell adhesion and interactions with the extracellular matrix (ECM). ITGA6 specifically pairs with either integrin beta 1 (ITGB1) or integrin beta 4 (ITGB4) to form the α6β1 and α6β4 integrins, which primarily bind to laminins, an essential component of the basement membrane. These integrin complexes play critical roles in tissue integrity, cellular architecture, and signal transduction, mediating functions such as cell adhesion, migration, proliferation, and differentiation. In pathological conditions, dysregulation of ITGA6 has been implicated in cancer progression, tissue fibrosis, and inflammatory diseases. Due to its involvement in cancer cell migration and invasion, ITGA6 is considered a potential therapeutic target, particularly in cancers of epithelial origin.
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