Rat Insulin Like Growth Factor 2 Receptor (IGF2R) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein IGF2R
proveedor
Abbexareference
abx067239Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
The insulin-like growth factor 2 receptor (IGF2R) is a multi-functional transmembrane protein primarily known for binding and internalizing insulin-like growth factor 2 (IGF-2). Unlike the insulin-like growth factor 1 receptor (IGF1R), which signals to promote cell proliferation and survival, IGF2R generally acts to limit the bioavailability of IGF-2 and is therefore considered a negative regulator of growth. IGF2R also binds other ligands, including mannose-6-phosphate-tagged proteins, such as lysosomal enzymes, which it transports from the Golgi to lysosomes. This receptor is widely expressed in mammalian tissues and has important roles in development, cellular signaling, and protein trafficking. IGF2R is unique in its signaling capacity, as it lacks intrinsic tyrosine kinase activity. It operates mainly through ligand sequestration, ligand degradation, and the modulation of signaling pathways indirectly by reducing IGF-2 interactions with IGF1R. IGF2R’s role in growth regulation and its involvement in diseases, particularly cancer, has made it a focal point in biomedical research.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Insulin Like Growth Factor 2 Receptor (IGF2R)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 28.3 kDa Observed MW (SDS-PAGE): 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val1146-Gln1363 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IGF2R
dry ice
No
availability
Shipped within 5-7 working days.
alias
Cation-independent mannose-6-phosphate receptor,MPR1,MPRI,CD222,CIMPR,M6P-R,MPR300,CI-M6PR,MPR 300,CI Man-6-P receptor,300 kDa mannose 6-phosphate receptor,IGF-II receptor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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