Human Insulin Like Growth Factor 2 Receptor (IGF2R) Protein

Este producto es parte de IGF2R - insulin like growth factor 2 receptor
Human Insulin Like Growth Factor 2 Receptor (IGF2R) Protein

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935106861

info@markelab.com

Precio

195€ (10 µg)

Protein IGF2R

proveedor

Abbexa

reference

abx067237

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

The insulin-like growth factor 2 receptor (IGF2R) is a multi-functional transmembrane protein primarily known for binding and internalizing insulin-like growth factor 2 (IGF-2). Unlike the insulin-like growth factor 1 receptor (IGF1R), which signals to promote cell proliferation and survival, IGF2R generally acts to limit the bioavailability of IGF-2 and is therefore considered a negative regulator of growth. IGF2R also binds other ligands, including mannose-6-phosphate-tagged proteins, such as lysosomal enzymes, which it transports from the Golgi to lysosomes. This receptor is widely expressed in mammalian tissues and has important roles in development, cellular signaling, and protein trafficking. IGF2R is unique in its signaling capacity, as it lacks intrinsic tyrosine kinase activity. It operates mainly through ligand sequestration, ligand degradation, and the modulation of signaling pathways indirectly by reducing IGF-2 interactions with IGF1R. IGF2R’s role in growth regulation and its involvement in diseases, particularly cancer, has made it a focal point in biomedical research.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Insulin Like Growth Factor 2 Receptor (IGF2R)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 31.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn2167-Ala2442 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IGF2R


dry ice

No


availability

Shipped within 5-7 working days.


alias

Cation-independent mannose-6-phosphate receptor,MPR1,MPRI,CD222,CIMPR,M6P-R,MPR300,CI-M6PR,MPR 300,CI Man-6-P receptor,300 kDa mannose 6-phosphate receptor,IGF-II receptor


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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