Rat HRH4 (Histamine Receptor H4) ELISA Kit
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name
Rat HRH4 (Histamine Receptor H4) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
ER1047
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.313-20ng/ml |
| Sensitivity | 0.188ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q91ZY1 |
| Alias | HRH4,GPCR105,HH4R,H4R,AXOR35, BG26,GPRv53 |
| Background | Elisa kits for HRH4 |
| Status | RUO |
HRH4 is a G protein-coupled receptor expressed predominantly in immune cells, such as mast cells, eosinophils, basophils, and T cells, where it regulates inflammatory and immune responses. HRH4 couples to Gi/o proteins, reducing cAMP levels and modulating calcium signaling, which influences chemotaxis, cytokine release, and immune cell activation. HRH4 plays a critical role in allergic inflammation, autoimmune diseases, and chronic inflammatory conditions, including asthma, dermatitis, and rheumatoid arthritis. Its activation enhances histamine-mediated recruitment of immune cells to inflammatory sites, amplifying the immune response. In addition to its role in peripheral tissues, HRH4 is expressed in the central nervous system, where it may modulate neuroinflammation and immune cell interactions. HRH4 antagonists are being investigated as potential therapeutics for inflammatory diseases, allergic disorders, and immune-mediated pathologies. Given its role in histamine-driven immune responses, HRH4 represents a promising target for modulating inflammation and improving outcomes in allergic and chronic inflammatory conditions.
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