Rat Histamine H3 Receptor (HRH3) Protein
1872€ (1 mg)
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935106861
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name
Rat Histamine H3 Receptor (HRH3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx653748
tested applications
WB, SDS-PAGE
Description
Rat Histamine Receptor H3 (HRH3) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Histamine H3 Receptor (HRH3) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | HRH3,GPCR97,H3R,HH3R |
| Background | Protein HRH3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
HRH3 is a G protein-coupled receptor primarily expressed in the central nervous system (CNS), particularly in histaminergic neurons, where it functions as an autoreceptor and heteroreceptor. HRH3 regulates the synthesis and release of histamine and modulates the release of other neurotransmitters such as dopamine, acetylcholine, and serotonin. It couples to Gi/o proteins, inhibiting adenylyl cyclase activity and reducing cyclic AMP (cAMP) levels, thereby regulating neuronal excitability and neurotransmission. HRH3 plays a critical role in cognitive processes, including attention, memory, and wakefulness, and is implicated in neurological and psychiatric disorders such as schizophrenia, ADHD, and neurodegenerative diseases like Alzheimer’s. Dysregulation of HRH3 signaling contributes to sleep disorders, cognitive dysfunction, and inflammatory neuropathies. HRH3 antagonists are being explored for therapeutic applications to improve cognition, treat sleep disorders, and manage neuropsychiatric conditions. Its role in presynaptic neurotransmitter modulation positions HRH3 as a promising target for CNS-related therapies.
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Rat Histamine H3 Receptor (HRH3) ELISA Kit
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