Rat Histamine H3 Receptor (HRH3) CLIA Kit
845€ (96 tests)
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name
Rat Histamine H3 Receptor (HRH3) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx495093
tested applications
CLIA
Description
Rat Histamine Receptor H3 (HRH3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Histamine H3 Receptor (HRH3) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.124 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | HRH3,GPCR97,H3R,HH3R |
| Background | CLIA Kits HRH3 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HRH3 is a G protein-coupled receptor primarily expressed in the central nervous system (CNS), particularly in histaminergic neurons, where it functions as an autoreceptor and heteroreceptor. HRH3 regulates the synthesis and release of histamine and modulates the release of other neurotransmitters such as dopamine, acetylcholine, and serotonin. It couples to Gi/o proteins, inhibiting adenylyl cyclase activity and reducing cyclic AMP (cAMP) levels, thereby regulating neuronal excitability and neurotransmission. HRH3 plays a critical role in cognitive processes, including attention, memory, and wakefulness, and is implicated in neurological and psychiatric disorders such as schizophrenia, ADHD, and neurodegenerative diseases like Alzheimer’s. Dysregulation of HRH3 signaling contributes to sleep disorders, cognitive dysfunction, and inflammatory neuropathies. HRH3 antagonists are being explored for therapeutic applications to improve cognition, treat sleep disorders, and manage neuropsychiatric conditions. Its role in presynaptic neurotransmitter modulation positions HRH3 as a promising target for CNS-related therapies.
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