Rat High Mobility Group Protein B1 (HMGB1) Protein

Product specifications

Proteins and Peptides

High Mobility Group Protein B1 (HMGB1)

E. coli

Rat

Unconjugated

Sequence Fragment: 2-215 AA.
Tag: N-terminal His tag
Validity: 6 months in liquid form, or 12 months in lyophilized form.

Recombinant

> 85% (SDS-PAGE)

20 µg

100 µg

1 mg

SDS-PAGE

Tris-based buffer, 50% glycerol.

Shipped within 5-15 working days.

Store at 4°C for up to one week. For extended storage, store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.

No

P63159

HMG1,HMG3,HMG-1,SBP-1,Amphoterin

Protein HMGB1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer

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