Rat High Mobility Group Protein B1 (HMGB1) Protein
481€ (20 µg)
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Name
Rat High Mobility Group Protein B1 (HMGB1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx600027
Tested Applications
SDS-PAGE
Description
Rat HMGB1 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | High Mobility Group Protein B1 (HMGB1) |
| Host | E. coli |
| Assay Type | Sequence Fragment: 2-215 AA. Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Tested Applications | SDS-PAGE |
| Buffer | Tris-based buffer, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at 4°C for up to one week. For extended storage, store at -20 °C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P63159 |
| Alias | HMG1,HMG3,HMG-1,SBP-1,Amphoterin |
| Background | Protein HMGB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer
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