Rat High Mobility Group Protein B1 (HMGB1) CLIA Kit
643.5€ (96 tests)
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name
Rat High Mobility Group Protein B1 (HMGB1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195764
tested applications
CLIA
Description
Rat High Mobility Group Protein B1 (HMGB-1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against High Mobility Group Protein B1 (HMGB-1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | High Mobility Group Protein B1 (HMGB1) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 12.5 pg/ml - 800 pg/ml |
| Sensitivity | 7.5 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | HMG1,HMG3,HMG-1,SBP-1,Amphoterin |
| Background | CLIA Kits HMGB1 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer
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