Rat Growth Factor Receptor Bound Protein 7 (GRB7) ELISA Kit

Este producto es parte de GRB - Growth factor receptor bound protein
Rat Growth Factor Receptor Bound Protein 7 (GRB7) ELISA Kit
715€ (96 tests)

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Name
Rat Growth Factor Receptor Bound Protein 7 (GRB7) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx526177
Tested Applications
ELISA

Description

Rat Growth Factor Receptor Bound Protein 7 (GRB7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Growth factor receptor-bound protein 7 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Growth Factor Receptor Bound Protein 7 (GRB7)
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9QZC5
Alias
GRB7, entrez:2886, growth factor receptor bound protein 7
Background
Elisa Kits for: GRB7
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

GRB7 is an adaptor protein that interacts with receptor tyrosine kinases (RTKs) like HER2, VEGFR, and IGF1R, linking them to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and focal adhesion kinase (FAK). GRB7 contains SH2, PH, and proline-rich domains, enabling its localization to membranes and interactions with signaling molecules involved in cell migration, adhesion, and proliferation. GRB7 is highly expressed in cancers, particularly HER2-positive breast cancer, ovarian cancer, and esophageal carcinoma, where it promotes tumor progression, metastasis, and angiogenesis. It also regulates integrin-mediated signaling pathways, playing roles in cell spreading and cytoskeletal organization. GRB7 dysregulation is associated with poor clinical outcomes in cancer patients due to its role in enhancing cell motility and survival. Knockdown studies show reduced tumor cell invasion, highlighting its potential as a therapeutic target in metastatic cancers.

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