Rat Growth Factor Receptor Bound Protein 2 (GRB2) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
611€ (96 tests)
Elisa kits for GRB2
proveedor
Abbexareference
abx353713Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Growth Factor Receptor Bound Protein 2 (GRB2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Growth Factor Receptor Bound Protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
GRB2 is an adaptor protein that links receptor tyrosine kinases (RTKs) to downstream signaling pathways, including Ras/MAPK and PI3K/Akt. It consists of one SH2 domain flanked by two SH3 domains, enabling it to interact with phosphorylated tyrosines and proline-rich regions of target proteins. GRB2 primarily binds to proteins like SOS (a Ras GEF), Shc, and PLCγ, facilitating Ras activation and subsequent signaling for cell growth, proliferation, and differentiation. GRB2 is essential for embryonic development, cellular homeostasis, and immune responses. Dysregulation of GRB2 contributes to oncogenesis, particularly in breast, lung, and gastric cancers, where it enhances cell proliferation and survival through constitutive Ras signaling. GRB2 also plays roles in immune cell signaling, particularly T-cell receptor activation and cytokine production. Knockout models demonstrate embryonic lethality, highlighting its critical function in cellular signaling and development.
Características del producto
category
ELISA Kits
immunogen target
Growth Factor Receptor Bound Protein 2 (GRB2)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
sensitivity
0.1 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GRB2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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