Rat GRB2-Associated-Binding Protein 2 (GAB2) ELISA Kit

Este producto es parte de GAB - GRB2 associated binding protein
Rat GRB2-Associated-Binding Protein 2 (GAB2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for GAB2

proveedor

Abbexa

reference

abx524638

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat GRB2-Associated-Binding Protein 2 (GAB2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat GRB2-associated-binding protein 2 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

GAB2 is a key adaptor protein that links receptor tyrosine kinases and cytokine receptors to intracellular signaling cascades, including PI3K/Akt, MAPK, and STAT pathways. It is predominantly expressed in hematopoietic cells, where it regulates immune cell activation, differentiation, and cytokine signaling. GAB2 interacts with GRB2, SHP2, and PI3K to modulate immune responses, hematopoiesis, and mast cell degranulation. Dysregulation of GAB2 is associated with inflammatory diseases, autoimmunity, and cancer, particularly leukemia, breast cancer, and melanoma, where it enhances cell proliferation, survival, and migration. Knockout studies highlight defects in immune cell activation, mast cell responses, and hematopoietic development, demonstrating its importance in immune regulation.

Características del producto

category

ELISA Kits


immunogen target

GRB2-Associated-Binding Protein 2 (GAB2)


reactivity

Rat


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

KIAA0571, Pp100,GRB2-Associated Binder


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

GAB2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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