Rat Interleukin-6 Receptor Subunit Beta (IL6ST) Protein

Este producto es parte de IL6ST - interleukin 6 cytokine family signal transducer Elisa - Clia - Antibody - Protein
Rat Interleukin-6 Receptor Subunit Beta (IL6ST) Protein
234€ (10 µg)

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Name
Rat Interleukin-6 Receptor Subunit Beta (IL6ST) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069730
Tested Applications
WB, SDS-PAGE

Description

Rat IL6ST Protein is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Interleukin-6 Receptor Subunit Beta (IL6ST)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Glu26-Asp323
Tag: N-terminal His tag and GST tag
Origin
Rat
Conjugation
Unconjugated
Observed MW
Calculated MW: 63.6 kDa  Observed MW (SDS-PAGE): 64 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P40190
Gene ID
25205
Alias
Interleukin-6 receptor subunit beta,CD130,GP130,HIES4,IMD94,STWS2,CDW130,HIES4A,HIES4B,IL-6RB,Sgp130,IL-6R subunit beta,IL-6R-beta,IL-6RB,Membrane glycoprotein 130,Oncostatin-M receptor subunit alpha
Background
Protein IL6ST
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

The interleukin 6 signal transducer (IL6ST), also known as gp130 or CD130, is a transmembrane protein that plays a crucial role in immune system regulation and cellular signaling. It functions as a common signal transducer for the IL-6 family of cytokines, which includes IL-6, IL-11, leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and others. These cytokines are involved in various physiological processes, including immune responses, hematopoiesis, inflammation, and tissue regeneration. IL6ST/gp130 is a key receptor component in the JAK/STAT signaling pathway and is widely expressed in various cell types, including immune cells, neurons, hepatocytes, and endothelial cells. Its broad expression and signaling capability allow it to mediate responses across different tissues, contributing to a range of cellular functions such as proliferation, differentiation, survival, and apoptosis. Dysregulation of gp130 signaling has been associated with multiple conditions, including autoimmune diseases, chronic inflammatory disorders, and various cancers.

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