Interleukin-6 Receptor Subunit Beta (IL6ST) Antibody
312€ (50 µl)
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935106861
info@markelab.com
name
Interleukin-6 Receptor Subunit Beta (IL6ST) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx011857
tested applications
ELISA, WB, IHC, IF/ICC
Description
CD130/IL6ST Antibody detects endogenous levels of total CD130/IL6ST. The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin-6 Receptor Subunit Beta (IL6ST) Immunogen: Synthesized peptide derived from human CD130 around the non-phosphorylation site of S782. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Observed MW | 160 kDa |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, containing 0.5% BSA, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P40189 |
| Gene ID | 3572 |
| OMIM | 600694 |
| Alias | Interleukin-6 receptor subunit beta,CD130,GP130,HIES4,IMD94,STWS2,CDW130,HIES4A,HIES4B,IL-6RB,Sgp130,IL-6R subunit beta,IL-6R-beta,IL-6RB,Membrane glycoprotein 130,Oncostatin-M receptor subunit alpha |
| Background | Antibody anti-IL6ST |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The interleukin 6 signal transducer (IL6ST), also known as gp130 or CD130, is a transmembrane protein that plays a crucial role in immune system regulation and cellular signaling. It functions as a common signal transducer for the IL-6 family of cytokines, which includes IL-6, IL-11, leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and others. These cytokines are involved in various physiological processes, including immune responses, hematopoiesis, inflammation, and tissue regeneration. IL6ST/gp130 is a key receptor component in the JAK/STAT signaling pathway and is widely expressed in various cell types, including immune cells, neurons, hepatocytes, and endothelial cells. Its broad expression and signaling capability allow it to mediate responses across different tissues, contributing to a range of cellular functions such as proliferation, differentiation, survival, and apoptosis. Dysregulation of gp130 signaling has been associated with multiple conditions, including autoimmune diseases, chronic inflammatory disorders, and various cancers.
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CD130/IL6ST Antibody detects endogenous levels of total CD130/IL6ST. The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors.
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