Rat Galanin Receptor Type 1 (GALR1) ELISA Kit

Product specifications

ELISA Kits

Galanin Receptor Type 1 (GALR1)

Rat

Colorimetric

Quantitative

Sandwich

0.78 ng/ml - 50 ng/ml

0.47 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q62805

50577

GALR1,GALNR,GALNR1,GAL1 receptor

Elisa kits for GALR1

RUO

Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

GALR1 is a G protein-coupled receptor (GPCR) that binds the neuropeptide galanin, mediating inhibitory signaling through coupling to Gi/o proteins. This interaction reduces intracellular cyclic AMP (cAMP) levels and modulates potassium and calcium channels, resulting in neuronal hyperpolarization and inhibition of neurotransmitter release. GALR1 is widely expressed in the central nervous system (CNS), including the hippocampus, hypothalamus, and spinal cord, where it regulates processes like pain modulation, mood regulation, and feeding behavior. In pain pathways, GALR1 activation suppresses nociceptive transmission, providing antinociceptive effects. GALR1 also exhibits neuroprotective properties in neurodegenerative disorders, such as Alzheimer’s disease, by reducing excitotoxicity. In cancer, GALR1 acts as a tumor suppressor, particularly in head and neck squamous cell carcinoma, where its activation inhibits cell proliferation and induces apoptosis. Dysregulation of GALR1 signaling is associated with mood disorders, including depression and anxiety, where impaired inhibitory signaling contributes to emotional imbalance. Its role in pain modulation, neuroprotection, and tumor suppression positions GALR1 as a promising therapeutic target for neurological disorders, pain management, and cancer therapy.

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