Rat Free Fatty Acid Receptor 1 (FFAR1) Protein

Product specifications

Proteins and Peptides

Free Fatty Acid Receptor 1 (FFAR1)

E. coli

Rat

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

FFAR1,GPR40,FFA1R,G protein-coupled receptor 40

Protein FFAR1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

FFAR1, also known as GPR40, is a G protein-coupled receptor primarily expressed in pancreatic β-cells, where it mediates the effects of medium- and long-chain free fatty acids (FFAs). FFAR1 activation enhances glucose-stimulated insulin secretion through Gq-mediated signaling pathways, including activation of phospholipase C (PLC), increased intracellular calcium, and protein kinase C (PKC) signaling. It plays a critical role in metabolic regulation by linking dietary fat intake to insulin release, thereby maintaining glucose homeostasis. FFAR1 is a promising therapeutic target for type 2 diabetes, where selective agonists are being explored to enhance insulin secretion without causing hypoglycemia. In addition to its metabolic role, FFAR1 is expressed in the brain and has been linked to neuroprotective functions. Dysregulation of FFAR1 signaling contributes to insulin resistance, obesity, and inflammation. Its dual role in metabolic regulation and neurological health positions FFAR1 as a key target for diabetes treatment and potential neurodegenerative therapies.

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