Rat Focal Adhesion Kinase 1 / FAK (PTK2) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rat Focal Adhesion Kinase 1 / FAK (PTK2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Focal Adhesion Kinase 1 / FAK (PTK2) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Focal Adhesion Kinase (FAK)
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Focal Adhesion Kinase 1 / FAK (PTK2) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | FAK,FADK,FAK1,FRNK,FADK 1,PPP1R71,p125FAK,pp125FAK,Focal adhesion kinase-related nonkinase,Protein phosphatase 1 regulatory subunit 71,Protein-tyrosine kinase 2 |
| Background | Elisa kits for PTK2 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Protein Tyrosine Kinase 2 (PTK2), also known as FAK (Focal Adhesion Kinase), is a non-receptor tyrosine kinase that plays a critical role in cell adhesion, migration, and signal transduction. PTK2 is primarily located at focal adhesion sites and is activated in response to integrin signaling and growth factor receptors. Structurally, PTK2 consists of an N-terminal FERM domain for membrane association, a central kinase domain for catalytic activity, and a C-terminal focal adhesion targeting (FAT) domain that mediates protein-protein interactions. PTK2 is crucial in cytoskeletal organization, integrin-mediated signaling, and cell motility, particularly in processes such as embryogenesis, wound healing, and angiogenesis. PTK2 is upregulated in various cancers, including breast, colorectal, and glioblastoma, where it promotes cell proliferation, survival, and metastasis. Dysregulation of PTK2 signaling can contribute to chemoresistance and increased tumor progression, making it a potential therapeutic target. In non-cancer contexts, PTK2 is essential for immune cell function, particularly for T-cell activation and macrophage responses. Additionally, PTK2 is implicated in neurological processes, such as synaptic plasticity and neuron survival. Its diverse roles make PTK2 a key mediator of cellular communication and mechanotransduction.
Related Products
Human PTK2(Focal adhesion kinase 1) ELISA Kit
Ver Producto
Protein Tyrosine Kinase 2 Beta (PTK2) Antibody
PTK2 Antibody is a Rabbit Polyclonal antibody against PTK2. This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Ver Producto
Mouse Ptk2 Antibody
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity). Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Ver Producto