Mouse Ptk2 Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Mouse Ptk2 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028067
tested applications
ELISA, WB
Description
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity). Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mouse Ptk2 |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P34152 |
| Alias | FAK,FADK,FAK1,FRNK,FADK 1,PPP1R71,p125FAK,pp125FAK,Focal adhesion kinase-related nonkinase,Protein phosphatase 1 regulatory subunit 71,Protein-tyrosine kinase 2 |
| Background | Antibody anti-PTK2 |
| Status | RUO |
Descripción
Protein Tyrosine Kinase 2 (PTK2), also known as FAK (Focal Adhesion Kinase), is a non-receptor tyrosine kinase that plays a critical role in cell adhesion, migration, and signal transduction. PTK2 is primarily located at focal adhesion sites and is activated in response to integrin signaling and growth factor receptors. Structurally, PTK2 consists of an N-terminal FERM domain for membrane association, a central kinase domain for catalytic activity, and a C-terminal focal adhesion targeting (FAT) domain that mediates protein-protein interactions. PTK2 is crucial in cytoskeletal organization, integrin-mediated signaling, and cell motility, particularly in processes such as embryogenesis, wound healing, and angiogenesis. PTK2 is upregulated in various cancers, including breast, colorectal, and glioblastoma, where it promotes cell proliferation, survival, and metastasis. Dysregulation of PTK2 signaling can contribute to chemoresistance and increased tumor progression, making it a potential therapeutic target. In non-cancer contexts, PTK2 is essential for immune cell function, particularly for T-cell activation and macrophage responses. Additionally, PTK2 is implicated in neurological processes, such as synaptic plasticity and neuron survival. Its diverse roles make PTK2 a key mediator of cellular communication and mechanotransduction.
Related Products
Human PTK2 (Focal adhesion kinase 1) ELISA Kit
Ver Producto
PTK2 antibody
Ver Producto