Rat Fc Fragment of IgG, Low Affinity IIb, Receptor For (CD32) (FCGR2B) Protein (Active)

Este producto es parte de FCGR2B - Fc gamma receptor Iib
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1079€ (100 µg)

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935106861
info@markelab.com
name
Rat Fc Fragment of IgG, Low Affinity IIb, Receptor For (CD32) (FCGR2B) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692451
tested applications
SDS-PAGE

Description

Rat CD32b Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat FCGR2B (Q63203-1) extracellular domain (Met 1-Pro 212) was expressed, fused with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
CD32b
Host
HEK293 cells
Origin
Rat
Observed MW
Molecular Weight: 21.9 kDa
Sequence Fragment: Met1-Pro212
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 97% (SDS-PAGE)
Size 1
100 µg
Size 2
1 mg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q63203-1
Alias
CD32,FCG2,CD32B,FCGR2,IGFR2,FCGR2C,FcGRIIB,FcRII-c,FcgammaRIIb,Low affinity immunoglobulin gamma Fc region receptor II-b,IgG Fc receptor II-b,CDw32,Fc-gamma RII-b
Background
Protein FCGR2B
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

FCGR2B (Fc gamma receptor IIB), also known as CD32B, is a low-affinity receptor for the Fc portion of IgG antibodies, primarily responsible for regulating immune responses by mediating inhibitory signaling. It plays a crucial role in the balance between activation and inhibition of immune cells, preventing excessive inflammation and autoimmunity. Unlike its closely related receptor, FCGR2A, which triggers activating signals, FCGR2B is the only inhibitory receptor within the Fc gamma receptor family. This receptor is predominantly expressed on B cells, dendritic cells, macrophages, and other immune cells. FCGR2B is part of the larger family of Fc gamma receptors (FcγRs), which bind the Fc region of immunoglobulin G (IgG) to mediate immune responses such as phagocytosis, cytokine release, and the clearance of immune complexes. Its inhibitory role is vital in the prevention of autoimmune reactions and the modulation of inflammatory responses.

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