Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b Phospho-Tyr292 (FCGR2B pY292) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b Phospho-Tyr292 (FCGR2B pY292) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012455
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against CD32 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b Phospho-Tyr292 (FCGR2B pY292) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr292 |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specifice phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P31994 |
| Alias | CD32,FCG2,CD32B,FCGR2,IGFR2,FCGR2C,FcGRIIB,FcRII-c,FcgammaRIIb,Low affinity immunoglobulin gamma Fc region receptor II-b,IgG Fc receptor II-b,CDw32,Fc-gamma RII-b |
| Background | Antibody anti-FCGR2B |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
FCGR2B (Fc gamma receptor IIB), also known as CD32B, is a low-affinity receptor for the Fc portion of IgG antibodies, primarily responsible for regulating immune responses by mediating inhibitory signaling. It plays a crucial role in the balance between activation and inhibition of immune cells, preventing excessive inflammation and autoimmunity. Unlike its closely related receptor, FCGR2A, which triggers activating signals, FCGR2B is the only inhibitory receptor within the Fc gamma receptor family. This receptor is predominantly expressed on B cells, dendritic cells, macrophages, and other immune cells. FCGR2B is part of the larger family of Fc gamma receptors (FcγRs), which bind the Fc region of immunoglobulin G (IgG) to mediate immune responses such as phagocytosis, cytokine release, and the clearance of immune complexes. Its inhibitory role is vital in the prevention of autoimmune reactions and the modulation of inflammatory responses.
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