Rat Endothelin 1 (EDN1) Protein

Este producto es parte de EDN1-Endothelin 1
Rat Endothelin 1 (EDN1) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein EDN1

proveedor

Abbexa

reference

abx066415

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Endothelin 1 (EDN1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

Endothelin-1 (EDN1) is a peptide hormone belonging to the endothelin family. It plays a crucial role in regulating blood vessel contraction and dilation, thereby influencing blood pressure and blood flow throughout the body. Endothelin-1 is primarily produced by endothelial cells, It is also produced by other cell types, including vascular smooth muscle cells, cardiomyocytes, and certain inflammatory cells.Endothelin-1 acts as a potent vasoconstrictor, meaning it causes blood vessels to narrow, leading to an increase in blood pressure. Dysregulation of endothelin-1 signaling is associated with several cardiovascular disorders, including hypertension, atherosclerosis, coronary artery disease, and pulmonary hypertension. Elevated levels of endothelin-1 have been observed in individuals with these conditions, contributing to their pathogenesis. Endothelin-1 is able to bind to specific receptors on target cells known as endothelin receptors. There are two main types of endothelin receptors: endothelin receptor type A (ETA) and endothelin receptor type B (ETB).

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Endothelin 1 (EDN1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 18.5 kDa Observed MW (SDS-PAGE): 19 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser54-His202 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

EDN1


dry ice

No


availability

Shipped within 5-7 working days.


alias

ARCND3,ET1, ET-1,HDLCQ7,QME,PPET1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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