Rat E3 Ubiquitin-Protein Ligase CBL-C (CBLC) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rat E3 Ubiquitin-Protein Ligase CBL-C (CBLC) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat E3 ubiquitin-protein ligase CBL-C concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | E3 Ubiquitin-Protein Ligase CBL-C (CBLC) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | G3V8H4 |
| Alias | CBL-C,CBLC,RNF57,CBL-SL,CBL-3 |
| Background | Elisa kits for CBLC |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CBLC is a member of the CBL family of ubiquitin ligases. It functions similarly to CBL and CBLB in modulating receptor signaling through ubiquitination. CBLC is involved in regulating the endocytosis and degradation of RTKs by promoting the ubiquitination of specific substrates. This regulation is essential in controlling the intensity and duration of signaling pathways that govern cell growth and differentiation. CBLC also plays a role in immune system signaling, where its activity contributes to the fine-tuning of immune cell activation. Like other CBL family members, CBLC is implicated in various diseases, including cancer and immune disorders, due to its role in regulating key cellular processes.
Related Products
CBLC antibody
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Ver Producto
E3 Ubiquitin-Protein Ligase CBL-C (CBLC) Antibody
CBLC Antibody is a Rabbit Polyclonal Antibody against CBLC.
Ver Producto
E3 Ubiquitin-Protein Ligase CBL-C (CBLC) Antibody
CBLC proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Ver Producto