E3 Ubiquitin-Protein Ligase CBL-C (CBLC) Antibody

Name: E3 Ubiquitin-Protein Ligase CBL-C (CBLC) Antibody
Brand: Abbexa
SKU: abx026905
Price: 292.5 EUR
Availability: OnlineOnly

Este producto es parte de CBLC - E3 ubiquitin-protein ligase

Pida mas información

935106861

info@markelab.com

Precio

292.5€ (80 µl)

Antibody anti-CBLC

proveedor

Abbexa

reference

abx026905

Tested Applications

ELISA, WB, IHC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

Background

CBLC is a member of the CBL family of ubiquitin ligases. It functions similarly to CBL and CBLB in modulating receptor signaling through ubiquitination. CBLC is involved in regulating the endocytosis and degradation of RTKs by promoting the ubiquitination of specific substrates. This regulation is essential in controlling the intensity and duration of signaling pathways that govern cell growth and differentiation. CBLC also plays a role in immune system signaling, where its activity contributes to the fine-tuning of immune cell activation. Like other CBL family members, CBLC is implicated in various diseases, including cancer and immune disorders, due to its role in regulating key cellular processes.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

E3 Ubiquitin-Protein Ligase CBL-C (CBLC)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC

purification

Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

recommended dilution

WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

CBLC

dry ice

availability

Shipped within 5-10 working days.

alias

CBL-C,CBLC,RNF57,CBL-SL,CBL-3

uniprot id

https://www.uniprot.org/uniprotkb/Q9ULV8

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anti- CBLC antibody

proveedor

FineTest

reference

FNab01319

Tested Applications

ELISA, WB

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then...

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