Rat DRD4 (Dopamine Receptor D4) ELISA Kit

Este producto es parte de DRD - Dopamine Receptor D
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935106861
info@markelab.com
name
Rat DRD4 (Dopamine Receptor D4) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
ER0912
tested applications
ELISA

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
ELISA Kits
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
4 hours
Assay Type
Sandwich ELISA, Double Antibody
Test Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Size 1
96T
Tested Applications
ELISA
Sample Type
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Availability
Shipped within 10-14 working days.
Storage
2-8 °C for 12 months
UniProt ID
P30729
Alias
DRD4,d(2C) dopamine receptor,dopamine receptor 4,D4R
Background
Elisa kits for DRD4
Status
RUO

DRD4 is a Gi/o-coupled G protein-coupled receptor of the D2-like dopamine receptor family, primarily expressed in brain regions associated with cognition, emotion, and reward, such as the prefrontal cortex, amygdala, and hippocampus. DRD4 plays a significant role in modulating attention, impulse control, and executive function, and its dysfunction has been linked to attention-deficit hyperactivity disorder (ADHD), schizophrenia, and other neuropsychiatric disorders. Notably, DRD4 is highly polymorphic, with variations in its gene (e.g., the 7-repeat allele) associated with ADHD susceptibility, novelty-seeking behavior, and addiction. DRD4 signaling inhibits adenylate cyclase activity, leading to reduced cyclic AMP (cAMP) levels, and influences downstream pathways like MAPK and protein kinase C (PKC), regulating neuronal excitability and plasticity. In addiction, DRD4 contributes to reward sensitivity and reinforcement learning, making it a target for substance abuse treatment. DRD4 is also expressed in peripheral tissues, where it modulates cardiovascular function and immune responses. Its polymorphic nature and role in attention and behavior make DRD4 a key target for ADHD therapeutics and neuropsychiatric research.

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