Dopamine Receptor D4 (DRD4) Antibody

Este producto es parte de DRD - Dopamine Receptor D
Product Graph
52€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Dopamine Receptor D4 (DRD4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015231
tested applications
WB, IF/ICC

Description

Rabbit polyclonal antibody against DRD4 protein. Immunogen region is C-terminal.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Dopamine Receptor D4 (DRD4)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
WB, IF/ICC
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P21917
Alias
DRD4,d(2C) dopamine receptor,dopamine receptor 4,D4R
Background
Antibody anti-DRD4
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

DRD4 is a Gi/o-coupled G protein-coupled receptor of the D2-like dopamine receptor family, primarily expressed in brain regions associated with cognition, emotion, and reward, such as the prefrontal cortex, amygdala, and hippocampus. DRD4 plays a significant role in modulating attention, impulse control, and executive function, and its dysfunction has been linked to attention-deficit hyperactivity disorder (ADHD), schizophrenia, and other neuropsychiatric disorders. Notably, DRD4 is highly polymorphic, with variations in its gene (e.g., the 7-repeat allele) associated with ADHD susceptibility, novelty-seeking behavior, and addiction. DRD4 signaling inhibits adenylate cyclase activity, leading to reduced cyclic AMP (cAMP) levels, and influences downstream pathways like MAPK and protein kinase C (PKC), regulating neuronal excitability and plasticity. In addiction, DRD4 contributes to reward sensitivity and reinforcement learning, making it a target for substance abuse treatment. DRD4 is also expressed in peripheral tissues, where it modulates cardiovascular function and immune responses. Its polymorphic nature and role in attention and behavior make DRD4 a key target for ADHD therapeutics and neuropsychiatric research.

Related Products

ER0912

Rat DRD4 (Dopamine Receptor D4) ELISA Kit

Ver Producto
FNab10944

DRD4 antibody

Ver Producto
abx002125

Dopamine Receptor D4 (DRD4) Antibody

DRD4 Antibody is a Rabbit Polyclonal antibody against DRD4. This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

Ver Producto