Rat Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit

Name: Rat Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit
Brand: Abbexa
SKU: abx256860
Price: 552.5 EUR
Availability: OnlineOnly

Este producto es parte de CYSLTR - Cysteinyl Leukotriene Receptor

Pida mas información

935106861

info@markelab.com

Precio

552.5€ (96 tests)

Elisa kits for CYSLTR2

proveedor

Abbexa

reference

abx256860

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat CYSLTR2 concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

CYSLTR2 is a G protein-coupled receptor that binds cysteinyl leukotrienes, particularly LTC4 and LTD4, with a lower affinity for LTE4. CYSLTR2 is expressed in smooth muscle cells, endothelial cells, and immune cells, where it mediates inflammatory responses similar to CYSLTR1. CYSLTR2 activation leads to smooth muscle contraction, increased vascular permeability, and cytokine production through the phospholipase C (PLC)/calcium signaling pathway. While CYSLTR1 is more involved in acute bronchoconstriction, CYSLTR2 appears to play a complementary role in chronic inflammation, fibrosis, and tissue remodeling. Dysregulation of CYSLTR2 contributes to diseases such as asthma, pulmonary fibrosis, and cardiovascular conditions, where cysteinyl leukotriene signaling promotes tissue damage and chronic inflammation. Emerging evidence suggests CYSLTR2's involvement in cancer progression, particularly in promoting tumor-associated inflammation and angiogenesis. Targeting CYSLTR2, in combination with CYSLTR1 antagonists, is being explored to improve therapeutic outcomes in severe asthma, fibrosis, and inflammatory diseases.

Características del producto

immunogen target

Cysteinyl Leukotriene Receptor 2 (CYSLTR2)

reactivity

Rat

test range

0.312 ng/ml - 20 ng/ml

sensitivity

0.19 ng/ml

assay type

Sandwich

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

size 2

5 × 96 tests

size 3

10 × 96 tests

alias

CYSLTR2,CYSLT2,CYSLT2R,GPCR21,HG57,HPN321,KPG_011,PSEC0146,hGPCR21,LTC4

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

CYSLTR2

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q924T9

gene id

https://www.ncbi.nlm.nih.gov/gene/170926

NCBI accession

NP_596904.1, XP_008769065.1

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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