Human Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit

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935106861
info@markelab.com
Precio
546€ (96 tests)
Elisa kits for CYSLTR2
proveedor
Abbexareference
abx252310Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Cysteinyl Leukotriene Receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
CYSLTR2 is a G protein-coupled receptor that binds cysteinyl leukotrienes, particularly LTC4 and LTD4, with a lower affinity for LTE4. CYSLTR2 is expressed in smooth muscle cells, endothelial cells, and immune cells, where it mediates inflammatory responses similar to CYSLTR1. CYSLTR2 activation leads to smooth muscle contraction, increased vascular permeability, and cytokine production through the phospholipase C (PLC)/calcium signaling pathway. While CYSLTR1 is more involved in acute bronchoconstriction, CYSLTR2 appears to play a complementary role in chronic inflammation, fibrosis, and tissue remodeling. Dysregulation of CYSLTR2 contributes to diseases such as asthma, pulmonary fibrosis, and cardiovascular conditions, where cysteinyl leukotriene signaling promotes tissue damage and chronic inflammation. Emerging evidence suggests CYSLTR2's involvement in cancer progression, particularly in promoting tumor-associated inflammation and angiogenesis. Targeting CYSLTR2, in combination with CYSLTR1 antagonists, is being explored to improve therapeutic outcomes in severe asthma, fibrosis, and inflammatory diseases.
Características del producto
category
ELISA Kits
immunogen target
Cysteinyl Leukotriene Receptor 2 (CYSLTR2)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
0.19 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
CYSLTR2,CYSLT2,CYSLT2R,GPCR21,HG57,HPN321,KPG_011,PSEC0146,hGPCR21,LTC4
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
CYSLTR2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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