Rat Collagen Type IV Alpha 3 (COL4A3) Protein
1235€ (100 µg)
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name
Rat Collagen Type IV Alpha 3 (COL4A3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693014
tested applications
SDS-PAGE
Description
Rat COL4A3 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat COL4A3 (NP_001129231) (Gly1426-His1670) was expressed with Fc region of human IgG1 at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Collagen Type IV Alpha 3 (COL4A3) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Gly1426-His1670 Tag: N-terminal Fc tag |
| Origin | Rat |
| Observed MW | 55.2 kDa |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_001129231 |
| Alias | ATS2,ATS3,BFH2,ATS3A,ATS3B,Goodpasture antigen |
| Background | Protein COL4A3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
COL4A3 is one of the six α-chains that compose type IV collagen, a major structural component of basement membranes. COL4A3 assembles into a triple-helical network with COL4A4 and COL4A5 to provide mechanical support, structural stability, and selective permeability in tissues such as the kidney glomerulus, lung alveoli, and the ocular lens. Mutations in COL4A3 are associated with Alport syndrome, a hereditary disorder characterized by progressive kidney disease, sensorineural hearing loss, and ocular abnormalities caused by defective basement membranes. It also plays a role in tissue repair and angiogenesis by interacting with signaling molecules such as integrins and matrix metalloproteinases (MMPs). Dysregulated COL4A3 expression contributes to fibrosis and tumor metastasis by influencing extracellular matrix (ECM) remodeling. Knockout models show abnormal glomerular basement membranes, hematuria, and progressive renal failure, highlighting COL4A3's critical role in basement membrane assembly, tissue integrity, and kidney function.
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