Collagen Type IV Alpha 3 Cleaved-Pro1426 (COL4A3 Cleaved-P1426) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Collagen Type IV Alpha 3 Cleaved-Pro1426 (COL4A3 Cleaved-P1426) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015580
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against COL4A3 protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:P1426.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Collagen Type IV Alpha 3 Cleaved-Pro1426 (COL4A3 Cleaved-P1426) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Cleaved // Target Modification: Pro1426 |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01955 |
| Alias | ATS2,ATS3,BFH2,ATS3A,ATS3B,Goodpasture antigen |
| Background | Antibody anti-COL4A3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
COL4A3 is one of the six α-chains that compose type IV collagen, a major structural component of basement membranes. COL4A3 assembles into a triple-helical network with COL4A4 and COL4A5 to provide mechanical support, structural stability, and selective permeability in tissues such as the kidney glomerulus, lung alveoli, and the ocular lens. Mutations in COL4A3 are associated with Alport syndrome, a hereditary disorder characterized by progressive kidney disease, sensorineural hearing loss, and ocular abnormalities caused by defective basement membranes. It also plays a role in tissue repair and angiogenesis by interacting with signaling molecules such as integrins and matrix metalloproteinases (MMPs). Dysregulated COL4A3 expression contributes to fibrosis and tumor metastasis by influencing extracellular matrix (ECM) remodeling. Knockout models show abnormal glomerular basement membranes, hematuria, and progressive renal failure, highlighting COL4A3's critical role in basement membrane assembly, tissue integrity, and kidney function.
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