Rat Cluster of Differentiation 40 Ligand / TNFSF5 (CD40LG) CLIA Kit

Rat Cluster Of Differentiation 40 Ligand (CD40L) CLIA Kit es un kit CLIA contra el Cluster Of Differentiation 40 Ligand (CD40L) en ratas.

Background

CD40 ligand (CD40LG), also known as CD154 or TNFSF5, is a transmembrane protein expressed primarily on the surface of activated T cells and, to a lesser extent, on platelets and other cell types. It is a key member of the tumor necrosis factor (TNF) superfamily and functions as a ligand for CD40, a receptor found on the surface of various immune cells, including B cells, dendritic cells, macrophages, and endothelial cells. CD40LG-CD40 interactions are essential for effective immune responses, promoting T-cell-B-cell cooperation, antigen presentation, and the production of antibodies. Mutations in CD40LG are linked to X-linked hyper-IgM syndrome (XHIM), a primary immunodeficiency disorder, highlighting the protein's importance in immune system regulation. The CD40LG-CD40 axis also plays a role in the development of autoimmune diseases, cardiovascular disorders, and cancer, where the interaction is implicated in chronic inflammation and pathological immune activation.