Rat Cholinergic Receptor, Muscarinic 1 (CHRM1) Protein

Este producto es parte de CHRM - Muscarinic acetylcholine receptor
Rat Cholinergic Receptor, Muscarinic 1 (CHRM1) Protein

Pida mas información

935106861

info@markelab.com

Precio

1872€ (1 mg)

Protein CHRM1

proveedor

Abbexa

reference

abx652147

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Cholinergic Receptor, Muscarinic 1 (CHRM1) Protein is a Recombinant protein from Rat.


Background

CHRM1 encodes the cholinergic receptor muscarinic 1, which is a member of the muscarinic acetylcholine receptor family. These receptors are G protein-coupled receptors (GPCRs) that mediate the actions of acetylcholine, a key neurotransmitter in the central nervous system (CNS) and peripheral tissues. CHRM1 is primarily expressed in the cerebral cortex, hippocampus, and basal ganglia, playing an essential role in cognitive processes such as learning, memory, and attention. Activation of CHRM1 leads to the stimulation of phospholipase C (PLC) via Gq/11 proteins, which increases intracellular calcium ion concentration and activates protein kinase C (PKC). Dysregulation of CHRM1 has been associated with neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and epilepsy. Pharmacologically, CHRM1 agonists enhance cognitive function, while antagonists can alleviate conditions like muscle spasms and excessive salivation. CHRM1 remains a critical target in neurodegenerative research, as modulation of this receptor may restore acetylcholine signaling and improve cognitive decline.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Cholinergic Receptor, Muscarinic 1 (CHRM1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

1 mg


size 2

5 mg


observerd MW

Molecular Weight: Calculated MW: 13.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser356-Cys460 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

CHRM1


dry ice

No


availability

Shipped within 1-2 months.


alias

CHRM1,M1 muscarinic acetylcholine receptor,Chrm-1,M1R,cholinergic receptor muscarinic 1,cholinergic receptor,cholinergic receptor, muscarinic 1,  M1 receptor,M1, HM1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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