Rat Cholinergic Receptor, Muscarinic 1 (CHRM1) Protein
208€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Rat Cholinergic Receptor, Muscarinic 1 (CHRM1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx652146
Tested Applications
WB, SDS-PAGE
Description
Rat Cholinergic Receptor, Muscarinic 1 (CHRM1) Protein is a recombinant protein from Rat.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Cholinergic Receptor, Muscarinic 1 (CHRM1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser356-Cys460 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 13.9 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08482 |
| Alias | CHRM1,M1 muscarinic acetylcholine receptor,Chrm-1,M1R,cholinergic receptor muscarinic 1,cholinergic receptor,cholinergic receptor, muscarinic 1, M1 receptor,M1, HM1 |
| Background | Protein CHRM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
CHRM1 encodes the cholinergic receptor muscarinic 1, which is a member of the muscarinic acetylcholine receptor family. These receptors are G protein-coupled receptors (GPCRs) that mediate the actions of acetylcholine, a key neurotransmitter in the central nervous system (CNS) and peripheral tissues. CHRM1 is primarily expressed in the cerebral cortex, hippocampus, and basal ganglia, playing an essential role in cognitive processes such as learning, memory, and attention. Activation of CHRM1 leads to the stimulation of phospholipase C (PLC) via Gq/11 proteins, which increases intracellular calcium ion concentration and activates protein kinase C (PKC). Dysregulation of CHRM1 has been associated with neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and epilepsy. Pharmacologically, CHRM1 agonists enhance cognitive function, while antagonists can alleviate conditions like muscle spasms and excessive salivation. CHRM1 remains a critical target in neurodegenerative research, as modulation of this receptor may restore acetylcholine signaling and improve cognitive decline.
Productos relacionados
Muscarinic Acetylcholine Receptor M1 (CHRM1) Antibody
CHRM1 Antibody is a Rabbit Polyclonal antibody against CHRM1. The muscarinic cholinergic receptors belong to a larger fa…
Ver producto
Muscarinic Acetylcholine Receptor M1 (CHRM1) Antibody
Rabbit polyclonal antibody against CHRM1 protein. Immunogen region is Internal.…
Ver producto
Rat Cholinergic Receptor, Muscarinic 1 (CHRM1) Protein
Rat Cholinergic Receptor, Muscarinic 1 (CHRM1) is a recombinant Rat protein expressed in E. coli.…
Ver producto