Rat Chemokine-like receptor 1 (CMKLR1) ELISA Kit

Product specifications

ELISA Kits

Chemokine-like receptor 1 (CMKLR1)

Rat

Colorimetric

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

0.063 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

O35786

CMKLR1,CHEMERINR,ChemR23,DEZ,ERV1,RVER1,chemokine receptor-like 1,Gpcr27,G-protein coupled receptor DEZ,resolvin E1 receptor,RVER1,tazarotene induced gene 2 receptor,TIG2 receptor

Elisa kits for CMKLR1

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

(CMKLR1), also known as ChemR23, is a G-protein-coupled receptor (GPCR) primarily activated by chemerin, a protein involved in immune responses and adipose tissue regulation. CMKLR1 is expressed in immune cells, such as macrophages, dendritic cells, and natural killer (NK) cells, as well as in adipocytes and smooth muscle cells. Its signaling plays a crucial role in inflammation and immune cell migration, especially during tissue injury or infection. CMKLR1 activation promotes macrophage recruitment to inflamed tissues, aiding in immune responses and wound healing. It also influences adipogenesis and metabolic regulation, contributing to energy balance and insulin sensitivity. CMKLR1 is implicated in cardiovascular diseases, where it regulates vascular inflammation and smooth muscle contraction, affecting blood pressure and vessel remodeling. Dysregulation of CMKLR1 signaling has been linked to metabolic disorders such as obesity, type 2 diabetes, and chronic inflammation. Moreover, CMKLR1 is being investigated as a target in autoimmune diseases and cancers, where its modulation could impact tumor microenvironments and immune evasion. The receptor's dual role in metabolic homeostasis and immune regulation positions it as a potential target for novel therapeutic interventions.

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