Rat CD59 Glycoprotein (CD59) ELISA Kit

Product specifications

ELISA Kits

CD59 Glycoprotein (CD59)

Rat

Colorimetric

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P27274

CD59 blood group,1F5,EJ16,EJ30,EL32,G344,MIN1,MIN2,MIN3,MIRL,HRF20,MEM43,MIC11,MSK21,16.3A5,HRF-20,MAC-IP,CD59 glycoprotein,MAC-inhibitory protein,MAC-IP,Membrane attack complex inhibition factor,MACIF

Elisa kits for CD59

RUO

Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

CD59 molecule (CD59) is a small, glycosylphosphatidylinositol (GPI)-anchored protein expressed on the surface of a wide variety of human cells. Its primary function is to inhibit the formation of the membrane attack complex (MAC) during the complement cascade, which is part of the immune system’s defense mechanism. By binding to components C8 and C9 of the complement system, CD59 prevents the insertion and polymerization of MAC into cell membranes, protecting host cells from lysis. This protective role is critical in maintaining cellular integrity and preventing autoimmune damage. CD59 also exhibits roles beyond complement regulation; it has been implicated in modulating T-cell activation and participating in signal transduction pathways through its interactions with other membrane proteins. Deficiency or dysfunction of CD59 is associated with certain pathological conditions, such as paroxysmal nocturnal hemoglobinuria (PNH), where red blood cells become highly susceptible to complement-mediated lysis. Additionally, CD59 is being studied for its potential role in cancer, as its overexpression in tumor cells may help them evade immune surveillance. Its broad cellular expression and functional versatility make CD59 a crucial regulator of immune and cellular processes.

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