Rat Breast Cancer Susceptibility Protein 1 (BRCA1) Protein
Pida mas información
935106861
info@markelab.com
Precio
260€ (10 µg)
Protein BRCA1
proveedor
Abbexareference
abx065606Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Breast Cancer Susceptibility Protein 1 (BRCA1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
BRCA1 is a tumor suppressor protein that plays a central role in maintaining genomic stability through its involvement in DNA damage repair, cell cycle regulation, and transcriptional control. BRCA1 functions as part of the homologous recombination repair pathway, where it recognizes and repairs double-strand DNA breaks, ensuring genomic integrity during cell division. It forms complexes with other DNA repair proteins, including RAD51, BARD1, and BRCA2, to facilitate accurate repair processes. BRCA1 also regulates cell cycle checkpoints, particularly at the G2/M phase, to prevent the propagation of damaged DNA. It is widely expressed in proliferative tissues, including breast and ovarian tissue, where its loss or mutation is associated with increased susceptibility to breast, ovarian, and other cancers. Mutations in BRCA1 disrupt its DNA repair function, leading to chromosomal instability, accumulation of mutations, and tumorigenesis. BRCA1 also interacts with signaling pathways involved in apoptosis, transcriptional regulation, and immune response, further highlighting its multifaceted role in cellular homeostasis. Knockout studies reveal defective DNA repair, increased tumorigenesis, and impaired cell cycle control, underscoring BRCA1’s critical function in DNA repair, tumor suppression, and genomic stability.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Breast Cancer Susceptibility Protein 1 (BRCA1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 58.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser1579-Glu1811 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
BRCA1
dry ice
No
availability
Shipped within 5-12 working days.
alias
BRCAI,BRCC1,BROVCA1,FANCS IRIS,PNCA4,PPP1R53,PSCP,RNF53,RING finger protein 53
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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